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วันเสาร์, 01 พฤศจิกายน 2568
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Herlitz et al. had been the primary to present a case sequence of 9 sufferers who developed FSGS after prolonged AAS use (169). A tenth patient described in their publication had no discrete lesions of segmental sclerosis however did have glomerulomegaly. All sufferers presented with proteinuria (mean 10.1 g/d; vary 1.3–26.three g/d) and all however one introduced with elevated serum creatinine levels (mean 265.3 μmol/L (3.0 mg/dL); vary 115.0–689.7 μmol/L (1.3–7.eight mg/dL)). It was also demonstrated that androgenic potency and metabolic resistance are positively linked to the diploma of liver injury [82]. The presence of apoptosis in brain areas of rats handled with long-term administration of nandrolone was instructed in a current study. In this regard, a link between oxidative stress and NF-Kb signaling was described, selling brain injury in particular areas, such because the hippocampus, striatum and frontal cortex [32]. Moreover, it was discovered that daily injections of stanozol in male adult rats for 28 days led to histopathologic changes in the hippocampus by activating apoptotic and pre-apoptotic cells [40]. It could additionally be argued that by today's standards this in vivo method, which was developed over 50 years in the past, is unsophisticated given the huge developments in molecular biology since that time. Regardless Of the criticism that this strategy has attracted, it's of notice that anabolic steroids with high myotrophic activity and beneficial index values, for example, nandrolone (esterified), oxymetholone, methandienone and stanozolol are still available as medicines in many international locations. These steroids stay desirable as a doping agent to reinforce sporting performance (as evident by the statistics collated by WADA) and for bodybuilding purposes. As an adjunct, a lot of the physiological significance of non-genomic actions of androgens is still to be elucidated, not least with respect to androgen-induced
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วันเสาร์, 01 พฤศจิกายน 2568
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